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Abstract
Pharmacokinetic and Pharmacodynamic theory and application has revolutionized the thoughts of neuropsychiatry and the fate of drugs in this complicated system. Neuropsychiatry dugs have done wonders in this decade. On the basis of diverse pharmacokinetic-pharmacodynamic modelling concepts, it has become possible to describe and predict the time course of drug effects under physiological and pathological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, summarizing extensive data, building a knowledge repository, finding optimal dosage regimen, and in making prediction under new circumstances. Evaluation of PK/PD assumes as a diagnostic tool for under lying disease effects.