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Nephrotic syndrome is a collection of symptoms due to the many nephrotic drugs and some diseases effecting to the kidney characterized by hypoproteinaemia, hyper cholesterolaemia, generalized edema and heavy proteinuria. Amikacin is the antibiotic which is used in treating many infectious diseases in children. It is having many side effects like nephrotoxicity, hypersensitivity reactions and Ototoxicity etc. The therapeutic dose of amikacin also leads to the nephrotoxicity in the childrens due to the pharmacokinetic and pharmacodynamic changes. Here in this case report a 10 years old female child was presented with facial puffiness, generalized edema, increased total cholesterol, decreased serum albumin and urine output due the usage of amikacin.