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The antihyperlipidemic activity in dexamethasone-induced hyperlipidemia in male Wistar rats, with the extracts of Achillea millefolium. The Extract showed to able to manage hyperlipidemia induced by high -fructose diet, reducing serum levels of total cholesterol and triglycerides, without signs may be indicated change in hepatic and renal function, suggesting that Extract is safe in the evaluated conditions. The hypolipidemic activity of natural products can be correlated to the presence of flavonoids due to their properties of inhibiting cholesterol biosynthesis and absorption and modifying the activity of lipogenic and lipolytic enzymes, l eading to reduced lipid metabolism, as observed in hyperlipidemic rats treated with Extract which showed important reduction in the levels of total cholesterol and triglycerides. Other molecules clever to decrease the serum level of cholesterol are saponins, also present in Extract. It is very interesting that Extract was able to reduce both serum level of cholesterol and total triglycerides.