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Abstract
The bark of Syzygium cumini bark are beneficial in treating the various other ailments, which is also accountable for its action on renal calculi preferably at this juncture. Cold maceration technique was used for the extraction of coarse powder of the plant bark and a total of 200g of Syzygium cumini was used to make a coarse powder. The Adult Wistar rats Swiss mice weighing between (20-30 g) were used to calculate LD50. In the present study, chronic induction of EG (0.75% v/v) to male wistar rats resulted in significant (P<0.001) increase in urinary excretion of calcium and phosphorous. Whereas the cystone-treated group III animals were shown significant reduction in calcium (P<0.0001) and phosphate (P<0.001) levels. Similarly treatment with plant extract significantly lowered the elevated levels of calcium (P<0.0001) and phosphate (P<0.0001) in 400 mg/kg as compared to EG induced group II animals. In conclusion, the aqueous extract of Syzygium cumini bark has both preventive as well as curative property in urolithiasis of rats