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Abstract
This study aims to evaluate the nephroprotective effect against Gentamicin-induced Nephrotoxicity (GM), and thus the antioxidant activity of an aqueous and Alcoholic extract rich in flavonoids from the Vaccinium oxycoccos. The antioxidant activity of was assessed using the Ferric reducing activity (FRAP assay), Metal Chelating activity, DPPH radical-scavenging activity, Superoxide radical-scavenging activity and Hydrogen peroxide scavenging activity. The nephroprotective effect of this extract was evaluated in two doses of 200 and 400 mg/kg in Albino Whister Rats. Acute toxicity of the Vaccinium oxycoccos was tested out on Swiss albino rates using 2000 mg/kg as the dose limit. The findings showed that the aqueous extract of Vaccinium oxycoccos is abundant in total polyphenols and flavonoids and has significant antioxidant properties. According to the acute toxicity research findings, the administered doses of the Vaccinium oxycoccos extract do not cause toxicity and death. Significant increases in the serum concentrations of Creatinine, urea, uric acid, as well as an increase in urinary volume, water consumption, and relative kidney weight, were all caused by the administration of Vaccinium oxycoccos to rats. Finally, Vaccinium oxycoccos extract enhanced Gentamicin biochemical and histological indicators of Nephrotoxicity, supporting its use as an ethno medicinal.