Tizanidine-Loaded Nanogel: Fabrication, Characterization, And Potential Biomedical Applications Of A Synthetic Polymer-Based Delivery System

Abstract

Nanogels, defined as highly cross-linked nano-sized hydrogel systems, offer unique advantages for drug delivery due to their hydrophilic networks capable of imbibing water or physiological fluids. This study focuses on the fabrication, characterization, and potential biomedical applications of a tizanidine-loaded nanogel using synthetic polymers. The nanogel was prepared using a homogenization technique, resulting in a stable O/W emulsion that transformed into nanogel. Characterization included Fourier-transform infrared spectroscopy (FTIR) for compatibility studies, particle size analysis using Malvern Zeta sizer, and zeta potential measurement. The drug content and release profile were evaluated using spectrophotometry and Franz diffusion cell, respectively. The optimized formulation (F9) demonstrated superior drug release (83.62% over 24 hours) and stability, with a particle size of 449 nm and zeta potential of 13.3 mV. In vitro release studies confirmed a sustained release pattern, enhancing cellular uptake and bioavailability. The study concludes that the tizanidine-loaded nanogel, formulated using cost-effective methods, can effectively deliver drugs transdermally, reducing administration frequency and side effects, making it a promising candidate for muscle spasm treatment.