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Abstract

Glycopyrrolate is an opioid pain medication used to treat moderate to moderately severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film was prepared by using polymers such as Sodium alginate, Pectin and HPMC by a solvent casting method.  They were evaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and In vitro Dissolution Studies give satisfactory results. The in vitro dissolution time of the optimized batch G7 was found to be 99.54%.  The optimized batch in vitro disintegration time was found to 15 sec.  

Keywords

Glycopyrrolate

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