Main Article Content
Abstract
The present study focuses on the formulation and evaluation of Thiocolchicoside-loaded transdermal patches aimed at providing sustained drug delivery, improving therapeutic efficacy, and enhancing patient compliance. Thiocolchicoside, a centrally acting muscle relaxant with poor oral bioavailability and gastrointestinal side effects, was incorporated into matrix-type transdermal patches using various polymers such as Hydroxypropyl methyl cellulose(mg), Sodium alginate(mg) and Sodium carboxymethyl cellulose(mg) along with suitable plasticizers.
The prepared patches were evaluated for their physicochemical properties including thickness, weight uniformity, folding endurance, moisture content, drug content, and surface pH. In-vitro drug release studies were conducted using Franz diffusion cells to assess the release profile of Thiocolchicoside over 12 hours. Among the various formulations, the optimized patch demonstrated satisfactory mechanical properties, high drug content uniformity, and a sustained drug release profile following like Higuchi or Korsmeyer-Peppas] kinetics.
The results suggest that transdermal delivery of Thiocolchicoside is a promising alternative to oral administration, potentially minimizing systemic side effects and improving patient adherence.
The prepared patches were evaluated for their physicochemical properties including thickness, weight uniformity, folding endurance, moisture content, drug content, and surface pH. In-vitro drug release studies were conducted using Franz diffusion cells to assess the release profile of Thiocolchicoside over 12 hours. Among the various formulations, the optimized patch demonstrated satisfactory mechanical properties, high drug content uniformity, and a sustained drug release profile following like Higuchi or Korsmeyer-Peppas] kinetics.
The results suggest that transdermal delivery of Thiocolchicoside is a promising alternative to oral administration, potentially minimizing systemic side effects and improving patient adherence.
Keywords
Thiocolchicoside-loaded transdermal patches
Article Details
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