Main Article Content
Abstract
Background: Drug-drug interactions (DDIs) are highly prevalent in geriatric patients due to polypharmacy, multimorbidity and age-related pharmacokinetic changes. This study aimed to assess the prevalence and patterns of potential DDIs in elderly inpatients.
Objectives: To evaluate prevalence, severity, mechanisms of DDIs and the influence of polypharmacy and comorbidities on DDIs in geriatric inpatients.
Methodology: A retrospective cross- sectional study was conducted on discharge medication records of 106 patients aged ≥60 years admitted during January-June 2022. DDIs were identified using drugs.com software and analyzed for prevalence, severity, mechanism and management.
Results: Out of 106 patients, 70.75% had at least one DDI. A total of 184 DDIs were detected with a mean of 1.74 DDIs per patient. Majority were moderate (72.83%) followed by minor (16.3%) and major (10.87%). Most were pharmacodynamic (61.41%) compared to pharmacokinetic (38.59%). Polypharmacy and comorbidities significantly influenced DDI prevalence (p<0.05).
Conclusion: High prevalence of DDIs emphasizes the need for routine medication review and monitoring in geriatric inpatients, especially those with polypharmacy and multiple comorbidities to improve medication safety.