Main Article Content
Abstract
To investigate the anti diabetic and anti Hyperlipidemic activity of methanol extract of Desmostachya Bippinnata in male Wistar rats.
Material & method: - In this model of Hyperlipidemia,30 adult male wistar rats (150-200gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively along with High Fat Diet and Triton x 100. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia.
In the model of anti diabetic animals were evenly divided into 5 groups
Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively after glucose loading.
Material & method: - In this model of Hyperlipidemia,30 adult male wistar rats (150-200gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively along with High Fat Diet and Triton x 100. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia.
In the model of anti diabetic animals were evenly divided into 5 groups
Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively after glucose loading.
Keywords
Desmostachya Bippinnata, Hyperlipidemia.
Article Details
References
- 1. Amit G, Vandana S, Sidharth M. HYPERLIPIDEMIA: An Updated Review. Inter J of Biopharma & Toxicol Res 2011;1:81-89.
- 2. Virchow RP, Thrombose IG. In Gesammelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt-am-Main, Meidinger Sohn & Company 1856, S 458-564.
- 3. Ankur rohilla, Nidhi Dagar, Seema Rohilla, Amarjeet Dahiya, Ashok Kushnoor. HYPERLIPIDEMIA- a deadly pathological condition. Inter J Curr Pharma Res 2012;4:15-18
- 4. Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med 1976;295:369-77.
- 5. Grundy SM, Vega GL. Hypertriglyceridemia: causes and relation to coronary heart disease - Semin. Thromb. Hemost 1988;14:249-64.
- 6. Dargel R. Lipoproteins and the etiopathogenesis of atherosclerosis. Zentralbl Allg Pathol 1989; 135: 501-504.
- 7. Kritchevsky D. Cholesterol vehicle in experimental atherosclerosis. A brief review with special reference to peanut oil. Arch Pathol Lab Med 1988; 112:1041 -4.
- 8. Ahmed SM, Clasen MD, Donnelly. MD: Management of dyslipidemia in adults. Amer, Family Physician 1998;57:1-16.
- 9. Fryar CD, Hirsch R, Eberhardt MS, Yoon SS, Wright JD. Hypertension, high serum total cholesterol, and diabetes: racial and ethnic prevalence differences in U.S. adults, 1999-2006. NCHS Data Brief 2010; 36: 1-8.
- 10. Ginsberg HN, Goldberg IJ. Disorders of lipoprotein metabolism. In: Harrison'sPrinciples of Internal Medicine. 15th Ed. New York: McGraw Hill;2001. 2245-2256.
- 11. Costet P. Molecular pathways and agents for lowering LDL-cholesterol in addition to statins. Pharmacol Ther 2010;126:263-78.
- 12. Ridker PM, Genest J, Boekholdt SM, Libby P, Gotto AM, Nordestgaard BG, et al. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet 2010;376:333-9.
- 13. Sundaram M, Yao Z. Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion. Nutr Metab (Lond) 2010;27:35.
- 14 Tripathi KD.Essentials of Medical pharmacology.6th ed. JP brothers medical publishers; 2008. p. 613-614.
- 15. Joseph T Dipiro. Pharmacotherapy: A pathophysiological approach. 6thed. The Mc Graw Hill companies, Inc. 2005. Pg. 429.
- 16. Kelly RB. Diet and exercise in the management of hyperlipidemia. Am Fam Physician. 2010;81: 1097-102.
- 17. Treatment Guidelines: Drugs for Lipid Disorders. The Medical Letter: August, 2003;12:77-82.
- 18. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Jama 2001;285:2486-2497.
- 19. Grauvogel J, Daemmrich TD, Ryschich E, Gebhard MM, Werner J. Chronic alcohol intake increases the severity of pancreatitis induced by acute alcohol administration, hyperlipidemia and pancreatic duct obstruction in rats. Pancreatol 2010;10:603-12.
- 20. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. National Cholesterol Education Program 1993: second report of the Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in AdultsŽAdult Treatment Panel II. J Am Med Assoc 1993; 269:3015-3023.