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Abstract
The main aim of the project a prospective study on due and appropriateness of prescribing cephalosporin’s in patients admitted in a tertiary care hospital. This study was conducted in inpatient medicine department in a tertiary care hospital. The all the patient admitted during the study period form inpatient basis were reviewed prospectively on daily basis by the study clinical pharmacist. The patient who met the study criteria was included into the study. The study results showed that the most prescribed cephalosporins were ceftriaxone, cefatoxime, cefexime, cefepime and ceftazidime. The most common infections were Enteric fever, pneumonia, AECB, meningitis, UTI, URTI, Septicemia, Skin and STD, Bone and Joint, Endocarditis. Out of 5 cephalosporins which are commonly prescribed by the clinicians of in a tertiary care Hospital, only ceftriaxone and cefotaxime was available in the hospital during the study period. Drug utilization guidelines increased the appropriateness of use of cephalosporins with respect to all the parameters. Maximum improvement was observed with respect to dose (21.67%), followed by avoiding drug interaction (18.66%), frequency of administration (23%), duration of therapy (9.88%) and choice of drug(13.68%). In conclusion this drug utilization evaluation study improved the use of cephalosporins in the medicine department. Results showed marked decrease in inappropriate use of cephalosporins and increased their appropriate use. The prepared guidelines for the use of cephalosporins had a positive impact in the clinical practice and was well accepted by the practitioners and proved to be useful in their clinical practice.