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Abstract
Background: This experimental study aimed to evaluate the wound healing potential of Gula Tunub, a unique honey variety from Lanao del Sur, Philippines, in Albino mice.
Methods: Conducted from December 19, 2023, to December 29, 2023, at Mindanao State University, Marawi City, Lanao del Sur, Southern Philippines, the research involved 45 Albino mice aged 3 to 6 months, distributed into three groups: T1 (100% Gula Tunub), T2 (Mixed Gula Tunub), and T3 (100% Normal Saline Solution). The study employed a controlled experiment with clinical observation methods, including wound excision model, treatment administration, and wound measurement. Data analysis involved One-Factor ANOVA and multiple comparison tests such as Tukey's HSD Test, Scheffé Test, and Bonferroni-Holm's Test.
Results: Findings indicated significant wound area reduction in the T1 group (100% Gula Tunub) over a 7-day period, suggesting its potential effectiveness in promoting wound healing. The T2 group (Mixed Gula Tunub) also showed promising results, with most mice achieving near-complete or complete healing by Days 6 to 7. The control group (T3) treated with Normal Saline Solution exhibited minimal progress in wound area reduction. Both Gula Tunub treatments demonstrated accelerated wound healing progress compared to the control.
Conclusion: The study suggests that Gula Tunub honey, especially in 100% and mixed concentrations, has potential as a wound healing treatment in Albino mice, surpassing the effects of Normal Saline Solution. Further research should delve into the mechanisms of Gula Tunub honey's healing properties for potential clinical applications in wound care. Ethical guidelines for animal research were followed in accordance with the National Institutes of Health's Guide for the Care and Use of Laboratory Animals.