Main Article Content
Abstract
Psoriasis is the prevailing chronic autoimmune disorder. Nevertheless, the topical application of this substance is hindered by frequent adverse effects such as skin shrinkage, steroidal acne, hypopigmentation, and allergic contact dermatitis. The primary aim of this work was to create topical gels of Wrightia tinctoria extract utilizing a cross-linker and polymer through the solvent emulsion diffusion method. It is employed in the treatment of Psoriasis. The nanosponges were produced using the solvent emulsion diffusion technique and assessed for Fourier transform infrared spectroscopy (FTIR) analysis, particle size determination, polydispersity index measurement, zeta potential measurement, drug content analysis, scanning electron microscopy examination, in vitro dissolution analysis, and stability assessment. The drug release and entrapment efficiency of all nanoparticles were assessed using in vitro methods. The tailored nanospheres were included in the gel to create a nano topical gel. All gel formulations underwent evaluation experiments to assess homogeneity, viscosity, spreadability, pH, and in vitro properties. The gels that were synthesized exhibited transparency, favorable viscosity, and spreadability. SEM images verified that the produced formulation exhibited a mostly spherical shape and possessed porosity. The drug release in the in vitro diffusion experiments was found to be 92.15% within a 24-hour period. The study indicates that the extract contains the active components for treating psoriasis, and the topical gel made from this extract has a notable impact in delivering the medication over a prolonged period of time.