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Abstract
Tinospora Cordifolia-loaded SLNs to improve its efficiency for treatment of diabetes. Tinospora Cordifolia-loaded SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Cholesterol) and stabilizers (Tween 80 or Span20) The physicochemical properties and the in vitro release study for all Tinospora Cordifolia-loaded SLNs were investigated. Furthermore, the optimized Tinospora Cordifolialoaded-SLN formula. The results showed that Tinospora Cordifolialoaded-SLNs were almost spherical shape having colloidal sizes with no aggregation. The drug entrapment efficiency ranged from 89% to near 100%. The zeta potential values lie between -10and -30 mV presenting good stability. From the results F4 considered as optimised formulation. Tinospora Cordifoliashowed prolonged in vitro release from SLNs dispersion. Findings of the study suggest that the developed Tinospora Cordifolialoaded SLNs have superior significant fast therapeutic index in treatment of diabetesThe preliminary phytochemical analysis of the Tinospora Cordifolia Solid lipid nanoparticles revealed the presence of Alkaloids, Tannins, Anthraquinones, Flavonoids, Saponins, Triterpenes, Sterols, Coumarinas the possible biologically active principles.