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           In the present research work floating matrix tablet formulation of Quetiapine Fumarate was prepared by using different polymers. Initially analytical method development was done for the drug molecule. And absorption maximum was determined based on the calibration curve developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of Hydroxyl Ethyl Cellulose (HEC), Chitosan, Sodium Alginate as polymeric substances. The formulations blend was subjected to various preformulations studies, flow properties. Among all the formulations, the formulation prepared with hydroxyl ethyl cellulose released the drug up to 24 hours (F3=99.84). The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed Kors Mayer peppas mechanism of drug release.    


Quetiapine Fumarate, Hydroxy Ethyl cellulose(HEC), Chitosan, Sodium alginate, Floating tablets.

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