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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Rosiglitazone in its pure form as well as in tablet dosage form. Chromatography was carried out on Apollo C18 (4.6 x 150mm, 5µm) column using a mixture of Methanol (100%v/v) as the mobile phase at a flow rate of 0.9ml/min, the detection was carried out at 265nm. The retention time of the Rosiglitazone was 3.379 min. The method produce linear responses in the concentration range of 25-125ppm of Rosiglitazone. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.


Rosiglitazone, RP-HPLC, validation.

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