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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Satranidazole and Ofloxacin, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6 x 150mm, 5µm) column using a mixture of Methanol: Water (80:20v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 310 nm. The retention time of the Satranidazole and Ofloxacin was 3.0, 4.0 ±0.02min respectively. The method produce linear responses in the concentration range of 20-100µg/ml of Satranidazole and 15-75µg/ml of Ofloxacin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.