Main Article Content
Abstract
Background and Objectives: Guillain–Barre syndrome (GBS), also known as Landry’s paralysis, is an immune-mediated disorder of nervous system of acute or subacute onset characterized commonly by generalized progressive weakness of arms and legs, limb paresthesias and relative or complete areflexia. The present study aimed at documenting clinical and electrophysiological profile and functional outcome of GBS patients along with seasonal variations.
Methods: An observational, cross-sectional study of 41 patients diagnosed with Guillian Barre syndrome admitted in Medicine wards and Medical Intensive Care Unit of Dept of Medicine, GMC, Aurangabad was conducted from October 2019 to October 2021. The data related to demographics, antecedent illness, muscle power on admission, Hughes score on admission and at discharge, CSF studies, electrophysiology, treatment given and the outcome of patients was studied.
Results: Mean age of subjects was 36.63 ± 19.2 years. Ascending paralysis was the most common presentation. In the study majority of cases (60.97%) had AIDP. In the study population, albumino-cytological dissociation in CSF findings was present in 37 patients out of 41(90.24%). There was statistically significant decrease in Hughes score at discharge compared to admission score. In the study 16 subjects required Ventilatory assistance. Among them 10 were discharged and 6 died.
Conclusion: Quadriparesis was the most common presentation among Guillian Barre syndrome patients. The majority of the patients had AIDP(Acute Inflammatory Demyelinating Polyneuropathy) subtype of GBS. There was statistically significant decrease in Hughes score in AIDP patients at discharge as compared to the Hughes score at admission. There was no seasonal variation in the occurrence of GBS.