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Rheumatoid arthritis is a chronic inflammatory and systemic auto immune disease affecting people for the most part between the ages of 20-25 yrs with accidental course. About 1% of the worlds population is afflicted by rheumatoid arthritis and is 2-3 times more common in women than men. The rheumatoid arthritis due to the presence of pro inflammatory markers, cytokines and leukotrines. The primary inflammatory markers are IL-1, TNF-α, IL-6, IL-15, IL-16, IL-17, IL-18, IFN-γ, and the granulocyte macrophage colony stimulating factor, chemokines such as IL-8, macrophage inflammatory protein-1 and monocyte chemo attractant protein-1. IL-1, TNF-α, IL-6, B cells therapy all these blockade are therapeutic target for its treatment. estimate the anti arthritic activity of the plants are used in different animal models to induced arthritis. Medicinal plants have been used as major sources of pure of human diseases since time immemorial. Now a days most of the people depends on traditional medicines of the plants. The medicinal plants derived medicines for the first time of primary health care because of least or no side effects.