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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Dolasetron, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Symmetry C18 (4.6 x 250mm, 5µm) column using a mixture of Acetonitrile and Water (50:50% v/v) as the mobile phase at a flow rate of 0.8ml/min, the detection was carried out at 285nm. The retention time of the Dolasetron was 3.0 ±0.02min. The method produce linear responses in the concentration range of 10-50ppm of Dolasetron. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.