Main Article Content
Abstract
In the present work, an attempt has been made to develop Sustained release tablets of Metoprolol by selecting natural polymers Tragacanth, Acacia gum, and Xanthan gum as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 99.63 % in 12 hours hence it is considered as optimized formulation F4 which contains Acacia gum (50 mg). Optimized formulation F4 was followed Higuchi release kinetics mechanism