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Huntington’s disease is an autosomal, dominant, slowly progressive, inherited, incurable, and a neurodegenerative disease characterized by uncontrolled motor movements, cognitive impairment, behavior abnormalities which may finally lead to dementia. The main cause of this disease is the mutation in the huntingtin gene, which is an IT 15 gene. The Occurrence of this disease is more in western countries between the age group of 35 to 45. Symptoms of this disease depend upon CAG triplet repeat. Main symptoms are chorea, athetosis, jerks, weight loss, difficulty in speech are seen. Symptomatic treatment may improve the quality of the life of the individual or may decrease complications.
Huntingtin gene(HTT) Cytosine adenosine guanine(CAG) Huntingtinprotein Tetrabenazine