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Objective of the current study is to develop colon targeted drug delivery systems for Curcumin. Eudragit S-100 and Ethyl cellulose is used as polymers in this drug delivery system. The colon targeted tablet was prepared by direct compression technique. Study of the preformulation characteristics and FTIR studies indicates that there was no interaction between Curcumin and excipients used. The formulated tablets were tested for both pre-compression parameters and post compression parameters as per requirements of standards. Pre-compression parameters such as bulk density, tapped density, compressibility index, Hausner’s ratio and compressibility index. The results obtained indicate that it has good flow property for direct compression. From among the entire batches, formulation F4 showed 98.90% drug release at 24 hrs. Since it provide greater protection to the core under acidic condition while at the same time show the fastest drug release under intestinal pH. So the trial F4 was considered as best formulation.