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A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Atorvastatin and Clopidogrel, in its pure form as well as in capsule dosage form. Chromatography was carried out on a Phenomenex Gemini C18 (4.6×250mm) 5µ column using a mixture of Methanol: TEA Buffer (65:35 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 230nm. The retention time of the Atorvastatin and Clopidogrel was 2.121, 3.643 ±0.02min respectively. The method produce linear responses in the concentration range of 5-25mg/ml of Atorvastatin and 30-187.5mg/ml of Clopidogrel. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.