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Oral insulin delivery which is more advanced and superior version of the insulin delivery. Diabetes mellitus is a chronic metabolic disease characterized by lack of insulin in body leading to failure of blood glucose regulation. Diabetic patients often require insulin injections which is a very painful administration method. If insulin administered orally, it cause enzymatic degradation in stomach, inactivation and digestion by proteolytic enzyme in intestinal lumen, poor permeability across intestinal epithelium and poor stability. This review article summarizes the problems associated with present route of insulin delivery, advantages of oral insulin delivery, existing barriers and encounter methods of oral insulin delivery


Oral insulin, diabetes, insulin delivery, Blood glucose.

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