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Viruses remain the predominant pathogens responsible for initiating respiratory tract infections in both community and healthcare settings. They continue to be common sources of morbidity in hosts and are especially related with substantial transience in recognised entities. As a result of changes in the human ecology brought on by global warming and increasing geographical movement of people and things, the risk of viral contagion has increased dramatically. Virus-caused infections of the respiratory system are the most prevalent disease in humans. Multiple etiologic surrogates impede the discovery of effective therapies. According to study, probiotics may lessen the risk or severity of respiratory infection symptoms. Probiotics can protect the host against a number of health issues, such as infectious infections. Prior to 1995, probiotics were believed to have only one effect: restoring the gut flora and preventing dangerous bacteria from causing gastroenteritis. Recent changes suggest that the immunomodulatory effect of probiotics is the most important mechanism of action. Numerous studies have demonstrated that specific probiotics may have antiviral properties due to their immunomodulatory activity. This review aims to inform readers about the effect of probiotics on respiratory virus infections and shed light on the putative antiviral mechanisms of probiotics.