Main Article Content


Ciprofloxacin and Ofloxacin are used to treat variety of Bacterial infections in Humans. These two drugs possess poor oral bioavailability as found from literatures. Ayurvedic literatures deal with the enhancement of oral bioavailability by TRIKATU (mixture of alcoholic extracts of dried fruits of Piper longum, dried fruits of Piper nigrum and dried rhizomes of Zingiber officinalis). The study was aimed to find out the efficacy of TRIKATU or its components in enhancing bioavailability of the above antibiotics. The extracts of components of TRIKATU were preparedby soxhlation using alcohol (90%). The study was carried out in rabbits by oral administration of the extracts of the components and their combination in equal proportions (TRIKATU) along with above antibiotics. Blood samples were drawn at time intervals equal to three half – lives of the antibiotics and their plasma concentrations were estimated microbiologically. TRIKATU enhanced the Bioavailability of Ciprofloxacin, but the components produced no effect on Ofloxacin Bioavailability. Trikatu has shown maximal enhancementfor both antibiotics



TRIKATU Bioavailability Ciprofloxacin Ofloxacin

Article Details