Main Article Content
Abstract
Conventional chemotherapy has limitations such as site non-specificity, inability of the drug to penetrate inside the tumor, adverse effects there by reducing the clinical application. So, in this study oxaliplatin solid lipid nanoparticles were prepared by emulsification solvent evaporation technique, the aim of this study was to investigate the effectiveness of a strategy based on the development of solid lipid Nanoparticles as an innovative formulation of oxaliplatin with improved therapeutic efficacy. The Oxaliplatin solid lipid nanoparticles were prepared by emulsification solvent evaporation technique by applying ultrasonic energy through Sonicator, The different formulations with various ratios of drug-lipid and surfactant were evaluated and optimised. The method used for the formulation of Oxaliplatin containing soya lecithin solid lipid nanoparticles was solvent evaporation method followed by sonication to reduce the particle size. The prepared nanosuspensions were characterised for particle size, surface morphology by SEM, drug excipient compatibility by FTIR and in-vitro drug release studies. Formulation (F-4) showed the highest encapsulation efficiency. In this research, a drug encapsulation efficiency as high as 93.56 % has been achieved. It was found that as the concentration of soya lecithin increased, the encapsulation efficiency was also increased. The present study revealed that solvent evaporation technique followed by sonication can be used as an effective tool for preparation of Oxaliplatin solid lipid nanoparticles. In conclusion, we demonstrate a preparation and characterization of oxaliplatin immuno nanoparticles for receptor mediated targeting of the drug.