Main Article Content
Abstract
The objective of the present study was to develop matrix-type transdermal therapeutic systems of Perindopril using various hydrophilic and hydrophobic polymers as matrix formers. Results revealed that prepared patches showed good physical characteristics, no drug-polymer interaction, and no skin irritation was observed. The in vitro release study revealed that F4 formulation showed maximum release in 8 hrs. Formulation F4 was subjected to accelerated stability studies. The F4 formulation was found to be stable as there was no drastic change in the Physico-chemical properties of the patches, which was also confirmed by FTIR. Thus conclusion can be made that stable transdermal patches of Perindopril have been developed. F1, F2, F3, F4 formulations showed the highest cumulative percentage drug release of 92.63%, 89.35%, 88.98%, 96.28% were obtained during in vitro drug release studies. The release of Perindopril appears to be dependent on the lipophilicity of the matrix. Moderately lipophilic matrices showed the best release. The predominant release mechanism of the drug through the fabricated matrices was believed to be by diffusion mechanism. Based upon the in vitro dissolution data the F4 formulation was concluded as an optimized formulation.