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Abstract

Antiphospholipid syndrome is an immunological condition that causes a recurrent venous or arterial thrombosis as well as foetal loss. APS is defined by persistently elevated levels of antibodies directed against membrane anionic phospholipids or their associated plasma proteins, primarily beta-2 glycoprotein I, or an evidence of a circulating anticoagulant. Women are five times more likely than men to be affected by APS. It’s also linked to pregnancy difficulties because it typically affects women in their 30s. Women with APS may have difficulty conceiving and blood clots in the placenta can lead to miscarriage, early birth, and development problems in newborns. Warfarin crosses the placenta and affects foetal coagulation, which increases the risk of bleeding complications in the foetus and during birth. Heparin is a mucopolysaccharide with a molecular weight ranging from 6,000 to 20,000 Daltons that is composed of numerous repeating units of glucuronic acid and sulphated glucosamine. Low molecular weight heparin is injected subcutaneously or intravenously and it works by activating antithrombin III, which then inactivates thrombin and factor Xa to generate its action. So treatment with anticoagulant drugs such as low molecular heparin is administered in combination with low dose aspirin which helps to prevent blood clots and miscarriages.

Keywords

Antiphospholipid low molecular weight heparin miscarriage

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