Main Article Content
Abstract
ABSTRACT
Introduction : Blood pressure can be defined as the force exerted by the blood against any unit area of the vessel wall. The systolic arterial pressure is the maximum pressure in the arteries during systolic phase. Diastolic pressure depends on cardiac output and peripheral vascular resistance. It has long been recognized that mortality and morbidity increase as both systolic and diastolic blood pressure rise. This may lead to changes in heart rate.
Aim & Objectives : To study effect of amlodipine, atenolol, enalapril and chlorothiazide on arterial blood pressure, heart rate and renal function tests.
Material & Methods : Study type is comparative observational study. Newly diagnosed hypertensive patient will be selected from medicine outpatient department randomly. Their blood pressure and heart rate was recorded manually while doing selection for study. If blood pressure recorded is ≥ 140/90, then only patient was included in the study. After that, these 120 patients will be divided in 4 group A, B, C, D. Each cohort contain 30 patients. Patient prescribed with amlodipine was considered as Group A, likewise prescription of atenolol was considered as group B, prescription of enalapril was considered as group C, and prescription of thiazide was considered as group D. After 15 days all patients were recalled for follow up. Their blood pressure and heart rate was be recorded. Same procedure was again repeat after 30 days from selection of patients for study. Renal function test was done before and after the study.
Results: In terms of effect on systolic blood pressure Enalapril has highest effect. On diastolic blood pressure Atenolol has highest effect. Mean arterial blood pressure was found to be higher decreased by Atenolol. Heart rate was significantly decreased by Atenolol Heart rate was increased by amlodipine. There was no effect of thiazide on heart rate. On blood urea level Atenolol was having maximum effect. Serum creatinine level was higher decreased by Atenolol.