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Background: plant parts of Grewia hirsute is one of the important medicinal plants belonging to the family plantae., with significant herbal uses like the bitter leaves lessen inflammation; useful in nose and eye disease; anthelmintic. The root of this variety is astringent to bowels; useful in cholera, hydrophobia, kidney pain, piles. The tasteless leaves used as purgative, expectorant, carminative, bortiofacient, emmenogaugue, vulnerary galactogoggue; useful in splenic enlargement, eye troubles, piles, rheumatism, pain in the joints and in the breasts. The plant Grewia hirsute also possess high quantities of significant phytoconstituents like alkaloids, flavonoids, phenols, glycosides, and coumarins which lead to use in many tropical countries. Due to its remarkable medicinal, nutritional and socio-economic value. This study was designed to clarify the protective effect of petroleium ether,ethyl acetate and ethanolic extract of Grewia hirsute against paracetamol induced hepatotoxicity in rats. Materials and Methods: Thirty six white Albino male rats were used in this study and after acclimatization rats were subjected to different treatments blood and tissue samples were collected after day 10 post administration, biochemical, and histopathological examinations were utilized to investigate hepatoprotective activity of all the three extract of Grewia hirsute. Result: Grewia hirsute showed significant protection with the depletion of alalinine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatise (ALP) gamma glutanyl transpeptidase, in serum as it was raised due to paracetamol induction. Concentration of serum triglycerides, total cholesterol and low density lipo protein were sceen to get reduced when treated with sylimarin as proven with administration of Grewia hirsute. There was amarkable increase in high density lipoprotein comparatively raise in total bilirubin and direct bilirubin was also reduced with administration of Grewia hirsute extract. Conclusion: From these results, it is suggested that Grewia hirsute possesses hepatoprotective properties.