Main Article Content
Abstract
Background
Antibiotics are medicines used to prevent and treat bacterial infections. Antibiotic resistance occurs, when bacteria change in response to the use of these medicines. Antibiotic resistance is the ability of a bacterium or other microorganisms to survive and reproduce in the presence of antibiotic doses that were previously thought effective against them. This study aims to evaluate resistant pattern in tertiary care hospital. Questionnaire based assessment of awareness of different measures taken for prevention of antibiotic resistance among health care workers.
Objective
To study antibacterial resistance pattern in tertiary care hospital with the help of culture sensitivity reports.
To study resistant pattern of bactericidal and bacteriostatic.
To identify antibacterial resistance pattern age wise, gender wise, region wise (taluka wise), indoor versus outdoor patient, and route wise.
Materials & methods
This is the prospective observational study conducted in tertiary care hospital, Pune. Total 200 patients blood culture sensitivity report was studied. Patient’s demographic details were recorded. The patients excluded were long standing chronic disorders like diabetes, kidney failure, liver failure, rheumatic arthritis, G-6PD deficiency individual and immune-deficiency individual. Study included bactericidal and bacteriostatic, gender-wise, age-wise, route of administration (oral and parenteral), region-wise, inpatient-outpatient analysis. Questionnaire was prepared to study awareness of measures taken for prevention of antibiotic resistance in health care workers
Results
Among 200 observed cases, resistance found 42.26% in male, and 43.75% in female. Antibacterial resistance found to be 27.52% in bacteriostatic agents and 40% in bactericidal agents. Antibacterial resistance found to be 65% inpatients and 23% in outpatients. Antibacterial resistance found to be highest in age group of 50-60 years having 52% and lowest in 20-30 years having 33%.Antibacterial resistance region-wise was found to be highest in Junnar taluka (70%) followed Daund (58%) and least resistance was found in Khed (35%).
Conclusion
There is an urgent need to develop and strengthen antibiotic policy, standard treatment guidelines and national plan for containment of resistance. Measure should be taken by the government with monitoring and evaluation of the existing health care delivery system for both health care providers and consumers to improve drug use, should be undertaken simultaneously.