Main Article Content
Abstract
Narcotics (e.g., opioids) or non-narcotics (e.g., salicylates and corticosteroids) are used in the management of pain and inflammation, both of which have side effects, thereby emphasizing the search for natural substances. The objective of the present study was to evaluate the acute toxicity study, analgesic, anti-inflammatory, and antipyretic activity of Meyna laxiflora Robyns seeds. In hot plate method, The tail immersion method and acetic acid-induced writhing method were used for the evaluation of analgesic activity. The carrageenan induced paw edema method, cotton pellet-induced granuloma methods were used for the evaluation of anti-inflammatory activity. Brewer’s yeast-induced pyrexia model was used to evaluate antipyretic activity. The aqueous and ethanolic seeds extract of M.laxiflora showed significant analgesic activity at 200 and 400 mg/kg. Analgesic activity was comparable with standard drug pentazocine. The maximum inhibitory effect of ethanolic extract of M.laxiflora showed significant (p< 0.01) at 90 min post dose in 400 mg/kg. Injection of acetic acid into control mice produced 51.4±6.4 writhes. Pre-treatment of extract, in this ethanolic extract significant effect of M.laxiflora reduced the number of writhes 39.4±2.4 (23.34 % protection) and 31.2±2.1 (39.29 % protection) respectively. The extract showed significant effect against Brewer’s yeast induced pyrexia method. The extract showed maximum decreased formation of granuloma tissue, which indicate that M.laxiflora produced a significant decrease in the weight of granuloma 38.16±0.04 (7.4% inhibition) and 34.58±0.04 (16.1% inhibition) respectively. The seeds of M.laxiflora Robyns exhibit significant analgesic, anti-inflammatory and antipyretic activity.