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Abstract
The liver performs diverse functions that are essential for life. In the absence of reliable liver protective drugs, a large number of natural medicinal preparations are used for the treatment of liver diseases. Therefore the present study aims to investigate the hepatoprotective effects of Salix Tribuluscistoidesethanolic extract against carbon tetrachloride (CCl4)-induced liver damage. Rats were divided into 6 groups of 6 animals each. Group I served as the normal healthy control, groups II rats were intoxicated with CCl4 i.p. (0.75ml of CCL4(25%) mixed with olive oil twice weekly for 9 weeks), Group 3: CCL4induced hepatotoxicity rats treated with Silymarin (25mg/kg) by i.p. Group 4: CCL4induced hepatotoxicity rats treated with ethanolic extract of Tribuluscistoides (100mg/kg) Group 5:CCL4induced hepatotoxicity rats treated with ethanolic extract of Tribuluscistoides(200mg/kg) Group 6: CCL4induced hepatotoxicity rats treated with ethanolic extract of Tribuluscistoides(400mg/kg) and biochemical analysis, Determination of purity of Tribuluscistoidesand histopathological studies was carried out. The administration of Tribuluscistoidesethanolic extract showed hepatic protection at an oral dose of 400 mg/kg. Tribuluscistoidesethanolic extract significantly reduced the elevated serum levels of intracellular liver enzymes as well as liver biomarkers in comparison to CCl4- intoxicated group. These findings were confirmed with the histopathological observations, where showed hepatic protection at an oral dose of 400 mg/kg. Tribuluscistoidesethanolic extract was capable of reversing the toxic effects of CCl4 on liver cells compared to that observed in CCl4-intoxicated animals. Our study show that Tribuluscistoidesethanolic extract has potential hepatoprotective effects at 400 mg/kg. These effects can be regarded to the antioxidant and anti-inflammatory properties of the extract.