Main Article Content
Abstract
To investigate the anti diabetic and anti Hyperlipidemic activity of methanol extract of Amaranthus in male Wistar rats.
Material & method
In this model of Hyperlipidemia,30 adult male wistar rats (150-200gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively along with High Fat Diet and Triton x 100. On last day, blood samples for biochemical parameters, were obtained under inhaled dietheranaesthesia.
Results
HFD and Triton x 100 treatment caused Hyperlipidemia as evidenced by marked elevation in Cholesterol, Triglycerides, LDL, VLDL and decrease in HDL levels. Co-administration of extract with HFD and Triton x 100 decreased rise Cholesterol, Triglycerides, LDL, VLDL and increase in HDL levels.
Conclusion
It was observed that the methanol extract of Amaranthusconferred Anti- Hyperlipidemia activitybybiochemical observationagainstHFD and Triton-x-100inducedHyperlipidemiainrats.Inthenearfuturecouldconstitutealeadtodiscoveryofanoveldrugfortreatmentofdruginduced Hyperlipidemia.