International Journal of Pharmacology and Clinical Research (IJPCR)

Pharmacological Evaluation Of Anti Depressant Activity Of Alangium Salviifolium (L. F.) Wangerin Leaves In Animal Models

MD. Safik Aziz Laskar, V. Umarani, K. Nagasree, K. Shravankumar — Fri, 17 Jan 2025 00:00:00 +0000

The objective was to investigate the antidepressant activity of methanolic extract of leaves of Alangium Salviifolium (L. F.) Wangerinin mice. To study the effect of Alangium Salviifolium (L. F.) Wangerin on anti depressant activity of brain. The results from the present study confirm the antidepressant activity of hibiscus, since it reduced the immobility in both FST and TST. In the present study, Alangium Salviifolium (L. F.) Wangerin is significantly increased the frequency of 5-HTP induced head twitches, Clonidine induced aggression and L-DOPA induced hyperactivity and aggressive behavior indicating its enhanced activity on serotonergic, noradrenergic and dopaminergic pathways respectively. Our results also confirm the involvement of serotonergic, noradrenergic and dopaminergic path ways in depression. Pre treatment with hibiscus, also significantly increased the levels of SOD and Catalase with simultaneous decrease in LPO levels in mice brain, suggesting its strong antioxidant activity. Since oxidative stress is reported to play an important role in depression, the antioxidant activity of Alangium Salviifolium (L. F.) Wangerin is might be a part of the mechanism for its antidepressant activity. Results from behavioral experiments indicate that the antidepressant activity of Alangium Salviifolium (L. F.) Wangerin is, might be due to the facilitatory effect on serotonergic, noradrenergic and dopaminergic systems apart from the anti depressant activity.

Nephroprotective Activity Of Heliotropium Indicum Extract On Gentamicin Induced Nephrotoxicity In Rats

Thirunamala Vaiahnavi, D. Swathi, V. Umarani, K. Shravankumar — Fri, 17 Jan 2025 00:00:00 +0000

Herbal medicine is the oldest form of healthcare known to mankind and most cultures have long folk medicine histories that include the use of plants. Nephrotoxicity is one of the most common kidney problems and occurs when the body is exposed to a drug or toxin that causes damage to the kidneys. To investigate the Nephroprotective activity of ethanol extract of Heliotropium indicum on Gentamicin induced Nephrotoxicity in male Wistar rats. Gentamicin treatment caused Nephrotoxicity as evidenced by marked elevation in blood urea, uric acid and Creatinine. Co-administration of extract with Heliotropium indicum decreased rise in blood urea, uric acid and Creatinine. Apart from these, histopathological changes also showed the protective nature of extract against Gentamicin induced necrotic damage of renal tissues. It was observed that the ethanol extract of conferred nephroprotective activity by histopathological and biochemical observation against Gentamicin induced Nephrotoxicity in rats. In the near future could constitute a lead to discovery of a novel drug for treatment of drug induced Nephrotoxicity.

A review on Antidiabetic nature of insulin plant (Costus ignues)

Hemant kumar singh, Ankita Singh, Md Ghazi Moazzam, Sanjit Singh — Mon, 20 Jan 2025 00:00:00 +0000

Medicinal plants have long been used as substitutes for prescription drugs. One of them is Costus igneus, a plant in the Costaceae family that is also referred to as the spiral flag or insulin plant. This plant is native to South and Central America, although it was just recently brought to India. Costus igneus is known for its capacity to nourish pancreatic beta cells and is frequently referred to as the "insulin plant" in India. With spiral-shaped leaves and eye-catching blossoms, this perennial, upright, spreading plant can grow up to two feet tall. Its medicinal usage has grown in prominence in recent years. The effectiveness of Costus igneus as an antidiabetic medication is highlighted in this review.