International Journal of Pharmacology and Clinical Research (IJPCR)

Symptoms and treatment strategy of black fungus in covid-19 patients

Dr. S. Kameshwaran — 2021-05-18

Mucormycosis, commonly called black fungus, is a rare but serious fungal infection caused by a kind of fungus called mucormycete, which is abundant in the environment. It mainly affects people who have health problems or take medicines that lower the body’s ability to fight germs and sickness. It is being detected relatively frequently among Covid-19 patients in some states of India. The disease often manifests in the skin and also affects the lungs and the brain. People who have been unwell with COVID-19 and are still recovering have a compromised immune system, which means they're more at risk because their body can't fight off the infection. Those who were hospitalized with severe COVID-19 disease were likely to be prescribed steroids for the reduction of infection. The steroid act by reducing the inflammation in the lungs and dampen the body's immune response in order to stop it attacking the body's healthy cells it leads to the decreased immune surveillance. Those patients were easily affected by means of mucormycete. While there is no major outbreak, the national Covid task force has issued an advisory regarding this disease.

A review on: Repurposed use of 2-deoxy-d-glucose as an adjunct therapy for covid-19 patients

Abishek.R — 2021-06-05

2-Deoxy-D-Glucose with its long run history as a trialling anti-cancer agent has now approved for the management of moderate to severe corona positive patients in India. So far 218 clinical trials are going on in oncology using this drug as intervention or else as adjunct. 2-Fluro-Deoxy-D-Glucose an analogue of 2-Deoxy-D-Glucose is also being used as a radiotracer. Glucose is the source of energy for all cells in human body. As an anti-glycolytic agent, 2-Deoxy-D-Glucose put the high glucose utilizing neoplastic cells at starvation and leads to autophagy. It can also destroy high glucose demanding healthy cell like neurons is also a matter of concern. The same anti-glycolytic property is responsible for halting the pathogenesis of Severe Acute Respiratory Syndrome Corona Virus-2.It is noteworthy that the drug can also reduce oxygen dependence in active corona patients. This review collectively examines the anti-cancer and anti-viral nature of 2-Deoxy-D-Glucose. It epitomises the pharmacodynamic potential of the drug in both oncology and virology. Listing out clinical trials conducted so far using this drug as an intervention in both oncology and virology and shedding light towards the adverse effects of this drug are also important objectives.

Phytochemical and pharmacological review study: Tecoma Stans Linn

Raju darla — 2021-06-14

Tecoma stans Linn is an erect shrub commonly found in India. It is also known as yellow bells, yellow elder, trumpet flower, belonging to the family Bignoniaceae. Tecoma stans, showed antidiabetic, antioxidant, hypoglycemic, antitumor, antiinflammatory and antimicrobial properties. This review aims at describing the botanical description, classification, phytochemical and pharmacological profiles. Tecoma stans is a dicotyledonous herb popularly grown for its flowers as anornamental /garden plant in normal gardens and temples. It is also known as Bignonia stans L. It has wide selection of medicinal and pharmacological applications. Almost all parts (leaves, root, flower, seed, fruit, and bark) of the plant are reported for its medicinal use. Tecoma stans could also be an herbal medicine used for treatment of diabetes, digestive problems, and control of yeast infections, as powerful diuretic, vermifuge and tonic. Preliminary phytochemical screening of this plant revealed the presence of tannins, flavonoids, alkaloids, quinones and traces of saponins and amino acids. This review supports all updated information on its phytochemical and pharmacological activities and its traditional uses.