International Journal of Pharmacology and Clinical Research (IJPCR) <p><strong><em>International Journal of Pharmacology and Clinical Research (IJPCR) </em></strong>is a peer-reviewed, quarterly official international journal allowing access to abstracts<strong>&nbsp;</strong>and<strong>&nbsp;</strong>full-text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (Pharmacology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Medicinal Chemistry, Computational Chemistry &amp; Molecular Drug Design, Pharmacognosy &amp; Phytochemistry, Pharmaceutical Analysis, Pharmacy Practice, Clinical &amp; Hospital Pharmacy, Cell Biology, Genomics &amp; Proteomics, Pharmacogenomics, Bioinformatics including biotechnology, cell &amp; molecular biology, Pharmaceutical biotechnology/microbiology, medical and other life sciences).</p> <p><strong>ISSN</strong>&nbsp;-&nbsp;<strong><em>International Journal of Pharmacology and Clinical Research (IJPCR)</em></strong></p> <p><strong>Online</strong>:<strong>&nbsp;</strong>2521-2206</p> <p><strong><em>International Journal of Pharmacology and Clinical Research </em></strong>seeks to foster multidisciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide an international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance. All manuscripts will be subjected to rapid peer review. Those of high quality (not previously published and not already under consideration for publication) will be published.</p> Dr.N.Sriram en-US International Journal of Pharmacology and Clinical Research (IJPCR) 2521-2206 Hibiscus Tea: A Natural Tea to Dwindle Hypercholesterolemia <p>Nowadays, there are many natural plant products that are widely used to reduce the increasing burden of diseases. Hibiscus rosa-sinensis Linn, which belongs to the family Malvaceae, is a plant distributed widely throughout the world. Its leaves, roots, barks, roots, and flowers are being used by the Indian traditional system as medicine to cure several diseases. Many research studies have proved that the different parts of the Hibiscus rosa-sinensis plant exhibit antioxidant, antimicrobial, anti-diabetic, anti-ulcer, hepatoprotective, anti-fertility, anti-genotoxic, anti-hypertensive, anti-hypercholesterolemia, and anti-inflammatory activities, which grab the scientific attention due to various biological activities. Hibiscus rosa-sinensis has been used in many herbal mixes and drinks. Various research studies have been conducted in animal models to evaluate Hibiscus rosa-sinensis flowers and leaves as anti-diabetic and antioxidant compounds. The present study is to mainly illuminate the antihypercholesterolemic effects of Hibiscus rosa-sinensis.</p> <p><strong>&nbsp;</strong></p> Uggirala Mounika Korampalli Saida Rao Shaik Arif Mohammed Copyright (c) 2023-04-20 2023-04-20 7 2 71 77 QbD Based Rp-Hplc Method Development And Validation for The Estimation Of Safinamide In Bulk And It’s Dosage form <p>A simple and selective HPLC method is described for the determination of Safinamide by QbDChromatographic separation was achieved on a Zorbax C18 (150mm×.4.6mm &amp; 5µm) usingmobile phase consisting of a mixture of pH 2.3 Buffer: Acetonitrile (64:34) with detection of226nm Linearity was observed in the range 50-150 µg /ml for Safinamide (r<sup>2</sup> =0.9997) for drugsestimated by the proposed methods was in good agreement with.3 the label claim. Thus, The RP-HPLC assay method developed for Safinamide by QbD approach is linear, accurate, precise,reproducible, and specific as evident from the validation results. The developed method is alsostability indicating and can be conveniently used for quality control to determine the assay inregular Safinamide product development, production, and stability samples.A new ReversePhase-HPLC method was developed for safinamide using Design Expert 9 software. In thissoftware, 3<sup>2</sup> factorial statistical designs were used to optimize the Critical Process Parameters orCritical Method Parameters and to evaluate interaction effects of these parameters on the CriticalQualityAttributes.</p> A.Raja Reddy Ajitha R. Kiran S. Sushmitha Sunitha.K Copyright (c) 2023-04-21 2023-04-21 7 2 78 90 Lantana camara: A review of Pharmacognostic studies and its traditional uses <p>Lantana camara is a well-known medicinal plant in traditional medicinal system. Lantana camara has a promising place in ayurvedic system of medicine due to its various medicinal values like antidiabetic, antiinflammatory, antibacterial , antifungal, antifertility etc. As per review of literature various parts of lantana camara have shown different pharmacological actions. Leaves have been reported for<strong> a</strong>ntiproliferative, antimicrobial, fungicidal, insecticidal and nematicidal, antimycobacterial, adulticidol, wound healing and anthelmintic activities. Whereas barks have shown antipyretic, and antispasmodic activity. Similarly fruits are reported for their Antidiabetic activity (in vivo). The fruit is unripe and these are inedible to human indigestion. fruits can result in serious damage to the digestive tract.</p> <p>Lantana camara is regularly used as herbal medicine and in some areas as firewood and mulch. Especially in India, there has been to a great extent work conducted on the chemical constituents of Lantana camara. The leaf oil is employed as an antiseptic for scars; the roots are used for the treatment of a toothache and the flowers for chest complaints in children. The plant is rich in carbohydrates, alkaloids, tannins, saponins and phenolic compounds which witness the ample of medicinal potential of the herb. Lantana camara leaves extract exhibited anti-proliferative, antimicrobial, fungicidal, insecticidal and nematicidal activities. Lantana camara shoots extract exhibited significant antioxidant activity. The berries fruits are useful in fistula, pocks, tumors and rheumatism. The essential oil of Lantana camara exposed a broad spectrum of antibacterial, antimicrobial, and antifungal activities<sup>[19] </sup>.&nbsp; In Lantana camara, chemical constituents are present as triterpenes like lantadenes A, B, C, and D, alkaloids, flavonoids, saponins, tannins, Germacrene A, B and D and chief compounds are Valencene and γ- gurjunene-3.</p> Narasimhachar Joshi Mohammed Ashfaqueullah Copyright (c) 2023-04-29 2023-04-29 7 2 91 101 Formulation Development and Characterization of Simvastatin Nanoparticles <p>Simvastatin Is A Lipid-Lowering Medication Drug Which Has Poor Bioavailability Due To Its Insolubility In Water And Belongs To Biopharmaceutics Classification-Ii. The Aim Of This Study Is To Enhance The Bioavailability Of Simvastatin By The Preparation Of Nanoparticles Using Emulsification Solvent Evaporation Method.&nbsp; In Present Work Different Formulations Were Prepared By Using Different Ratios Of Polymer, Span 60. Prepared Nanoparticle Was Evaluated For Its Particle Size, Zeta Potential, Scanning Electron Microscopy, Percentage Practical Yield, Drug Entrapment Efficiency, And In-Vitro Drug Release Studies. Among All The Formulations Dissolution Studies Showed That F3 Formulation Containing 5% Ethyl Cellulose And Eudragit 1:3% As Controlled Release Property And Releases 99.82% At 12h Of Drug In Intestinal Ph (6.8). The Prepared Nanoparticles Forms A Polymer Matrix There By Releases The Drug In A Controlled Manner.</p> Gargi Debnath Mithun Bhowmick Tulshi Chakraborty Pratibha Bhowmick Copyright (c) 2023-05-08 2023-05-08 7 2 102 111 Formulation and evaluation of microsphere of entecavir <p>In the present work, Microspheres of Entecavir using PLGA and Chitosan as polymers were formulated to deliver Entecavir via oral route. The results of this investigation indicate that Ionotropic gelation technique can be successfully employed to fabricate Entecavir microspheres. In this work an effort was made to formulate microsphere of Entecavir by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by FTIR and <em>in vitro</em> drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Entecavir. The present study conclusively that Entecavir microsphere could be prepared successfully and formulation F3 was shows satisfactory result.</p> SK. Faruk Mithun Bhowmick Pritam Saha Pratibha Bhowmick Copyright (c) 2023-05-13 2023-05-13 7 2 112 121 Study on the post-covid impact among the patients, based on their comorbidities <p><strong><em>Background</em></strong><em>:</em> Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global health crises and strained health resources. COVID-19 is now known to be a multi-organ disease with a wide range of symptoms.</p> <p><strong><em>Objectives</em></strong><em>:</em> To assess that those who reported COVID-19 with comorbidities have high risk as compared to those without comorbidities.</p> <p><strong><em>Methodology</em></strong><em>:</em> To better understand and characterize symptoms os post COVID-19 patients, a retrospective cohort analysis was conducted. Five hundred and eighty-three post COVID patients with and without comorbidities were selected for this cross-sectional study. Symptoms occurrence and severity were studied through questionnaires. Relative risk (RRs) were calculated by Chi square test where statistical significance was set as P&lt;0.05.</p> <p><strong><em>Results</em></strong><em>:</em> Out of 583 post COVID patients, we have 196 (33.61%) comorbid patients and 387 (66.38%) non-comorbid patients. The most common comorbidity was diabetes mellitus. By analyzing 257 comorbid cases, we had diabetes (29.57%), hypertension (22.17%), pulmonary disorder (23.34%), cardiovascular disorder (8.56%), renal disorder (2.33%), tumor (0.38%), obesity (8.94%), cerebrovascular disease (0.38%0 followed by dyslipidemia (4.28%). Also, by comparing the risk on respiratory and cardiovascular symptoms in post COVID-19 patients, we found that comorbid patients have more risk as compared to non-comorbid patients. We found risk on respiratory was significant (P=0.003248).</p> <p><strong><em>Conclusion</em></strong><em>:</em> COVID-19 patients with comorbidity have high risk as compared to patients without comorbidity. We also found that patients with comorbidity have more deteriorating outcomes compared with patients without.</p> <p><strong>&nbsp;</strong></p> Shantiya K Arathi P Riya Shafna M T Sreekutty M K G.Babu Tamil Jothi E Copyright (c) 2023-05-25 2023-05-25 7 2 122 131