Effectiveness of exercise therapy with dry needling technique for trigeminal neuralgia- a scoping review

S. Jeyakumar — 2025-04-16

This scoping review explores the current state of literature on exercise therapy in conjunction with dry needling for trigeminal neuralgia. Despite the recognized efficacy of exercise therapy and dry needling in various musculoskeletal conditions, their application for trigeminal neuralgia remains underexplored. The review underscores the urgent need for more extensive research, pointing out the limited number of articles identified. Recommendations for future studies include prioritizing larger sample sizes, adopting rigorous methodologies, and ensuring diverse participant populations to strengthen the evidence base. Diverse study designs, encompassing randomized controlled trials, longitudinal studies, and qualitative research, are encouraged to provide a comprehensive understanding of the potential benefits and limitations of exercise therapy with dry needling. Interdisciplinary collaboration involving neurologists, pain specialists, physical therapists, and researchers is deemed essential to design and implement effective exercise therapy protocols, acknowledging the complexity of trigeminal neuralgia. Long-term follow-up assessments are proposed to evaluate the sustained effects of interventions, contributing crucial insights for informing clinical practice. Emphasis on patient-centered outcomes, including pain intensity, quality of life, and patient satisfaction, is advocated to enhance the relevance and applicability of interventions. Limitations of the scoping review, such as the limited available literature, heterogeneity in study designs, publication bias, and variability in exercise protocols, are acknowledged. The importance of addressing safety concerns, especially when combining exercise therapy with dry needling, is highlighted. The review concludes with a call for future studies to address these recommendations and limitations, aiming for a more robust evidence base for the application of exercise therapy with dry needling in managing trigeminal neuralgia.

Evaluation of In Vitro Antiurolithiatic Activity and Antioxidant Activity of Moringa oleifera Lam. leaves

S. Santhosh — 2025-05-13

The study investigates the in vitro antiurolithiatic and antioxidant potential of ethanolic extracts of Moringa oleifera Lam. leaves. Urolithiasis, a prevalent and recurring urinary tract disorder, affects millions worldwide and has been linked to metabolic and lifestyle factors. Due to limitations and adverse effects associated with conventional treatments, alternative herbal therapies are gaining interest. In this study, Moringa oleifera leaves were collected, authenticated, and extracted using the Soxhlet method with ethanol. Phytochemical screening revealed the presence of bioactive compounds such as flavonoids, alkaloids, glycosides, saponins, and phenolics. The antioxidant activity was evaluated using DPPH and hydrogen peroxide scavenging assays, with the extract demonstrating IC₅₀ values of 71.31 μg/ml and 94.98 μg/ml, respectively, comparable to ascorbic acid. The antiurolithiatic activity was assessed through calcium oxalate aggregation assay, showing a maximum inhibition of 39.96% at 500 μg/ml. The presence of phenolic and flavonoid compounds is believed to contribute significantly to the observed pharmacological effects. The results suggest that Moringa oleifera possesses substantial antioxidant and antiurolithiatic properties and could serve as a promising herbal remedy. Further in vivo and mechanistic studies are recommended to validate and understand its therapeutic role in urolithiasis management

International Journal of Pharmacology and Clinical Research (IJPCR)

Effectiveness of exercise therapy with dry needling technique for trigeminal neuralgia- a scoping review

Evaluation of In Vitro Antiurolithiatic Activity and Antioxidant Activity of Moringa oleifera Lam. leaves