International Journal of Pharmacology and Clinical Research (IJPCR) https://ijpcr.net/ijpcr <p><strong><em>International Journal of Pharmacology and Clinical Research (IJPCR) </em></strong>is a peer-reviewed, quarterly official international journal allowing access to abstracts<strong>&nbsp;</strong>and<strong>&nbsp;</strong>full-text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (Pharmacology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Medicinal Chemistry, Computational Chemistry &amp; Molecular Drug Design, Pharmacognosy &amp; Phytochemistry, Pharmaceutical Analysis, Pharmacy Practice, Clinical &amp; Hospital Pharmacy, Cell Biology, Genomics &amp; Proteomics, Pharmacogenomics, Bioinformatics including biotechnology, cell &amp; molecular biology, Pharmaceutical biotechnology/microbiology, medical and other life sciences).</p> <p><strong>ISSN</strong>&nbsp;-&nbsp;<strong><em>International Journal of Pharmacology and Clinical Research (IJPCR)</em></strong></p> <p><strong>Online</strong>:<strong>&nbsp;</strong>2521-2206</p> <p><strong><em>International Journal of Pharmacology and Clinical Research </em></strong>seeks to foster multidisciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide an international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance. All manuscripts will be subjected to rapid peer review. Those of high quality (not previously published and not already under consideration for publication) will be published.</p> Dr.N.Sriram en-US International Journal of Pharmacology and Clinical Research (IJPCR) 2521-2206 Comparative clinical evaluation of analgesics on kerala zone https://ijpcr.net/ijpcr/article/view/473 <p>The WHO in 1977 has characterized drug usage as advertising conveyance solution and utilization of medications general public with unique accentuation subsequent clinical social and monetary results. Aim of the study is to evaluate drug utilization / prescription pattern of Analgesics prescribed in Post operative patients in a tertiary care hospital. In our sample size 802 patients was determined. Hence total number of 1504 patients was enrolled in the study out of which 802 patients who met the inclusion and exclusion criteria were finally included in the study at discharge and at 3 6 and 9 months follow-up period after discharge from the hospital. &nbsp;Results expressed that The solution investigation aftereffects of absolute number of related illnesses in Kerala zone demonstrated that 802 Numbers and 53.5% which incorporates assortment of sicknesses like Hypertension Hyperlipidemic Infections Thyroid illnesses Inflammation Myocardial Infraction Congestive Heart Failure Angina Pectoris Asthma Ulcer IBS Depression Tachyarrthymias Bradyarrthymiasis and Psychosis. Post-employable related Patients commonness dramatically more (493 Numbers and 61.5%) when contrasted with Pre usable Patients (POP) related Patients (309 Numbers and 38.5%). Interior POP dependent on the relative assertion showed Pain related Myocardial Infarction (56 Numbers and 7 %) patients.</p> <p><strong>&nbsp;</strong></p> Shaimol. T G. Babu. Copyright (c) 2023-07-13 2023-07-13 7 3 142 148 Assessment of Medication Adherence Pattern for Patients with Chronic Diseases in South Indian Hospitals https://ijpcr.net/ijpcr/article/view/476 <p>There is a need for specialized medication education programs for rural patients because of the limited health care services and low literacy level. The objectives of the study are to evaluate the pattern of medication knowledge of hypertensive patients living in the rural area with they are consultation in various south Indian district and Primary Health Care hospitals and to assess the impact of pharmacist provided education sessions on their medication knowledge status. A total of 1500 rural hypertensive patients were randomized into control and intervention group. Intervention group patients were educated regarding their medications, whereas control group patients did not receive any education by the study pharmacist during initial stage, 150<sup>th</sup>, 300<sup>th</sup> and 450th day. Medication knowledge was assessed by administering medication knowledge assessment questionnaire, which was administered to control and intervention groups during the follow-up visits and&nbsp; eighty days after the last follow-up (530<sup>th</sup> day). At starting point there was no statistically significant (p&gt;0.05) variance in the medication knowledge scores of the intervention and control groups. After the pharmacist provided education sessions there was an improvement in the medication knowledge assessment scores of intervention group patients were observed with reference to recall of medication name, dose, indication, side effects, duration of treatment, usefulness, effectiveness and missed medicines (p&lt;0.05). Demographic variables such as female gender, lower education and income were the determinants of lower medication knowledge. Pharmacist provided education sessions contributed in enhancing the medication knowledge of the intervention group patients. Our study findings warrant the necessity of educating the rural patients with chronic disease conditions to improve the knowledge regarding their medications.</p> Karibasappa Mathad V K. Sattanathan Copyright (c) 2023-07-19 2023-07-19 7 3 149 158 RP-HPLC method for estimation of abacavir, lamivudineas per ich guidelines https://ijpcr.net/ijpcr/article/view/480 <p>A novel, precise, accurate, rapid and cost effective isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method was developed, optimized and validated for the estimation of Abacavir and Lamivudine in bulk and pharmaceutical dosage forms. The drugs were estimated using Phenomenex Gemini C18 (4.6mm×150mm, 5.0 µm) particle size column. A mobile phase composed of tri ethylamine buffer and methanol in proportion of 32:68 v/v, at a flow rate of 1.0 ml/min was used for the separation. Detection was carried out at 248 nm. The linearity range obtained was 30-70 µg/ml for Darunavir and 10-50 µg/ml for Cobicistat with retention times (Rt) of 3.297 min and 5.405 min for Abacavir and Lamivudine respectively. The correlation coefficient values were found to be 0.999 &amp; 0.999. Precession studies showed % RSD values less than 2 % for both the drugs in all the selected concentrations. The percentage recoveries of Abacavir and Lamivudine were found to be 100.1873% for Darunavir and 100.748% for Cobicistat respectively. The assay results of Abacavir and Lamivudine were found to be 99.82%. The limit of detection (LOD) and limit of quantification (LOQ) were 2.6µg/ml and 7.8µg/ml for Darunavir and 3.4µg/ml 10.2µg/ml for Cobicistat respectively. The proposed method was validated as per the International Conference on Harmonization (ICH) guidelines. The proposed validated method was successfully used for the quantitative analysis of commercially available dosage form.</p> Vasamsetti Himduja B. Sravanasree T.K.V. Kesav Rao Copyright (c) 2023-08-15 2023-08-15 7 3 159 167 A new simple and specific RP-HPLC method development and validation for the simultaneous determination of linagliptin and metformin in bulk and tablet dosage form https://ijpcr.net/ijpcr/article/view/481 <p>A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Linagliptin and Metformin, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×250mm) 5µ column using a mixture of Water and Acetonitrile (50:50) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 244nm. The retention time of the Linagliptin and Metformin was 2.0, 4.0±0.02min respectively. The method produce linear responses in the concentration range of 20-100µg/ml of Linagliptin and 40-200µg/ml of Metformin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.</p> Gali Veera Venkata Satya Surya Prakasa Rao T.K.V. Kesav Rao Ch.Prasad Copyright (c) 2023-08-15 2023-08-15 7 3 168 176 Determination of atorvastatin and clopidogrel by using RP-HPLC method in pure and its pharmaceutical dosage form https://ijpcr.net/ijpcr/article/view/482 <p>A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validation of Atorvastatin and Clopidogrel, in its pure form as well as in capsule dosage form. Chromatography was carried out on a Phenomenex Gemini C18 (4.6×250mm) 5µ column using a mixture of Methanol: TEA Buffer (65:35 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 230nm. The retention time of the Atorvastatin and Clopidogrel was 2.121, 3.643 ±0.02min respectively. The method produce linear responses in the concentration range of 5-25mg/ml of Atorvastatin and 30-187.5mg/ml of Clopidogrel. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.</p> Kollu Naveen Kumar A. Venkateswara Rao B. Sravanasree Copyright (c) 2023-08-15 2023-08-15 7 3 177 186 An overview general aspects of chrozophora rottleri – Suryavarti https://ijpcr.net/ijpcr/article/view/483 <p>The blooming shrub <em>Chrozophora rottleri</em>, also referred to as "Indian chalk plant," is indigenous to India and other countries in South Asia. The ability of this plant to create a white, chalk-like substance on its leaves, stems, and fruits is just one example of its unusual traits. The powdery coating has long been employed in a variety of cultural rituals and may have medical and cosmetic uses as well. February through August are prime months for development to begin. It first arises in February, blooms in June and July, and then entirely vanishes in late August. The plant has a staggering array of chemical components as well as numerous pharmacological characteristics. The plant contains artificial chemical compounds such as alkaloids, sugar, glycosides, tannins, steroids, flavonoids, saponins, quercetin 3-o-rutinoside, acacetin 7-orutinoside, and apigenin 7-o-b-d-[6-(3,4- dihydroxybenzoyl)] -glucopyranoside. Xanthone glycosides and chromone glycoside were abundant in the leaf and basic parts of<em> C. rottleri</em>. The whole plant contains tannins, and oil extracted from the seeds was very lineolate-rich. Powdered leaves and roots are administered for the treatment of colds, coughs, and wound healing. <em>Chrozophora rottleri </em>is a plant that has antibacterial, antioxidant, antinecrotic, and antihelmintic characteristics.The study of the euphorbiaceae family, botanical description, taxonomical classification, phytochemical constituents, medicinal uses, pharmacological and therapeutic activity aspects of <em>Chrozophora rottleri</em> are covered in this abstract, which also highlights the plant's importance in regional customs and potential value for further investigation</p> Prema. R Ari Haran K Logesh T.G Saran kumar E Soundariya C Nandhitha V Senthil kumar. C Copyright (c) 2023-08-18 2023-08-18 7 3 187 194 Formulation development and invitro characterization of rutin nanoparticles https://ijpcr.net/ijpcr/article/view/485 <p>Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate Carbopol p934 nanoparticles containing Rutin in different drug to polymer ratio. SEM indicated that nanoparticles have a discrete spherical structure. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The <em>in vitro </em>release behavior from all the drug loaded batches was found to be first order release and provided sustained release over a period of 12 h. The developed formulation overcome and alleviates the drawbacks and limitations of Rutin sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Saxagliptin.</p> M.Swapna Koteswari Poluri Copyright (c) 2023-09-06 2023-09-06 7 3 195 203 Formulation and evaluation of curcumin tablets for colon drug delivery systems https://ijpcr.net/ijpcr/article/view/491 <p>Objective of the current study is to develop colon targeted drug delivery systems for Curcumin. Eudragit S-100 and Ethyl cellulose is used as polymers in this drug delivery system. The colon targeted tablet was prepared by direct compression technique. Study of the preformulation characteristics and FTIR studies indicates that there was no interaction between Curcumin and excipients used. The formulated tablets were tested for both pre-compression parameters and post compression parameters as per requirements of standards. Pre-compression parameters such as bulk density, tapped density, compressibility index, Hausner’s ratio and compressibility index. The results obtained indicate that it has good flow property for direct compression. From among the entire batches, formulation F4 showed 98.90% drug release at 24 hrs. Since it provide greater protection to the core under acidic condition while at the same time show the fastest drug release under intestinal pH. So the trial F4 was considered as best formulation.</p> Mohammed Shafi T. Soumya Koteswari Poluri Copyright (c) 2023-09-09 2023-09-09 7 3 204 214