International Journal of Pharmacology and Clinical Research (IJPCR)

https://ijpcr.net/ijpcr/issue/feed International Journal of Pharmacology and Clinical Research (IJPCR) 2026-02-21T05:18:23+00:00 Dr.N.Sriram ijpcreditor@gmail.com Open Journal Systems International Journal of Pharmacology and Clinical Research (IJPCR) is a peer-reviewed, quarterly official international journal allowing access to abstracts and full-text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (Pharmacology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Medicinal Chemistry, Computational Chemistry & Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmaceutical Analysis, Pharmacy Practice, Clinical & Hospital Pharmacy, Cell Biology, Genomics & Proteomics, Pharmacogenomics, Bioinformatics including biotechnology, cell & molecular biology, Pharmaceutical biotechnology/microbiology, medical and other life sciences). ISSN - International Journal of Pharmacology and Clinical Research (IJPCR) Online: 2521-2206 International Journal of Pharmacology and Clinical Research seeks to foster multidisciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide an international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance. All manuscripts will be subjected to rapid peer review. Those of high quality (not previously published and not already under consideration for publication) will be published. https://ijpcr.net/ijpcr/article/view/613 Formulation and Evaluation of Thiochochicoside Loaded Trandermal Patches 2026-02-21T05:14:53+00:00 Sibasish Barik pravatguru79@gmail.com Pravat Ranjan Guru pravatguru79@gmail.com Satya Ranjan Dalai pravatguru79@gmail.com Ashish Pandab pravatguru79@gmail.com

The present study focuses on the formulation and evaluation of Thiocolchicoside-loaded transdermal patches aimed at providing sustained drug delivery, improving therapeutic efficacy, and enhancing patient compliance. Thiocolchicoside, a centrally acting muscle relaxant with poor oral bioavailability and gastrointestinal side effects, was incorporated into matrix-type transdermal patches using various polymers such as Hydroxypropyl methyl cellulose(mg), Sodium alginate(mg) and Sodium carboxymethyl cellulose(mg) along with suitable plasticizers. The prepared patches were evaluated for their physicochemical properties including thickness, weight uniformity, folding endurance, moisture content, drug content, and surface pH. In-vitro drug release studies were conducted using Franz diffusion cells to assess the release profile of Thiocolchicoside over 12 hours. Among the various formulations, the optimized patch demonstrated satisfactory mechanical properties, high drug content uniformity, and a sustained drug release profile following like Higuchi or Korsmeyer-Peppas] kinetics. The results suggest that transdermal delivery of Thiocolchicoside is a promising alternative to oral administration, potentially minimizing systemic side effects and improving patient adherence.

2026-02-21T00:00:00+00:00 Copyright (c) https://ijpcr.net/ijpcr/article/view/614 Formulation and Characterization of Transdermal Patches for Controlled Delivery of Fravotriptan for the Treatment of Migraine 2026-02-21T05:18:23+00:00 Sonali Monalisha pravatguru79@gmail.com Satya Ranjan Dalai pravatguru79@gmail.com Pravat Ranjan Guru pravatguru79@gmail.com Rajat Kumar Kar pravatguru79@gmail.com

The present study focuses on the formulation and characterization of transdermal patches for the controlled delivery of Fravotriptan, a selective 5-HT1B/1D receptor agonist used in the treatment of migraine. Due to its short half-life and extensive first-pass metabolism, the oral delivery of Fravotriptan often results in reduced bioavailability and frequent dosing. To overcome these limitations, transdermal drug delivery systems (TDDS) offer a promising alternative by maintaining sustained drug release, enhancing patient compliance, and minimizing systemic side effects. In this research, transdermal patches were formulated using varying concentrations of hydrophilic (HPMC E15) and hydrophobic Ethyl cellulose and Eudragit RL100, EC) polymers through the solvent casting method. Polyethylene glycol 400 (PEG-400) was employed as a plasticizer to improve flexibility and mechanical strength. The prepared patches were subjected to various physicochemical evaluations, including thickness, weight uniformity, folding endurance, tensile strength, moisture content, moisture uptake, drug content uniformity, pH, and in vitro drug release studies using Franz diffusion cells.Among all the formulations, the optimized patch demonstrated uniform thickness, high folding endurance, suitable drug content, and sustained drug release up to 12 hours, following Higuchi kinetics, suggesting a diffusion-controlled release mechanism. The optimized patch also exhibited good physical stability during short-term storage conditions. This study successfully demonstrates the potential of transdermal patches as an effective system for the controlled and sustained delivery of Fravotriptan, offering a patient-friendly approach for the management of migraine.