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Abstract
Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Bacopa Monnieri was investigation for antidepressant activity. Antidepressant activity of ethanolic extract of Bacopa Monnieri (EEBM) was investigated by using Forced swimming test (FST) and Tail suspension test (TST) models. Imipramine was used as reference standards. It has been observed from our study that both the EEBM at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model of depression comparable to Imipramine. However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity.