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Abstract

Gastroretentive dosage forms  have  potential  for  use  as  controlled-  release drug  delivery systems. The aim of the  present  study  is  formulation  and  characterization  of  floating  microspheres  using Orlistat as a model drug for the management of Orlistat is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. Floating microspheres were prepared by solvent evaporation technique using Sodium alginate, Guar gum, and Hpmc as release retarding polymers. The floating microspheres were evaluated for percentage yield (%), Mean particle size, drug content, drug entrapment efficiency, In vitro Buoyancy and in vitro drug release studies. Compatibility studies were performed by  fourier  transform  infrared  (FTIR)  technique. The prepared microspheres showed prolonged drug release of 12 h. The optimized formulation (F4) showed better drug release 97.36 % for 12 hours. It was concluded that developed floating microspheres of Orlistat offers a suitable and practical approach for  prolonged  release  of  drug  over  an  extended  period  of  time  and  thus  oral  bioavailability, efficacy and patient compliance is improved.            

Keywords

Orlistat Floating Microspheres Sodium alginate Guar gum and Hpmc

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