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Abstract
The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. Rofecoxibis a Nonsteroidal anti-inflammatory drug (NSAID) drug which is purely insoluble in water. Since only dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is ultimately desired. Solubility of the poorly soluble drug, Rofecoxib, is enhanced by formulating solid dispersion using Direct Compression method. Drug and carriers like Mannitol and PVP- K30in different ratios like 1: 1, 1: 2, 1: 3, 1:4, 1:5 and 1:6were used for formulating solid dispersions. The FTIR spectra of the Rofecoxib and polymers alone and in combination show the compatibility of the drug and excipients. The solid dispersions wereevaluated for practical yield and in vitro dissolution. It was concluded that 1:2 ratio of Drug: PVP- K30 shows better in vitro dissolution rate. Further the solid dispersion with highest release rate was formulated in tablet dosage form. The angle of repose, bulk density, tapped density, carr’s index and hausner ratio were calculated for the micromeritic characterization of the powder blend. The tablets were further studied for different pharmacopoeial and non pharmacopoeial evaluation test. Rofecoxib was found to be within the standards.