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Recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions characterize behcet's disease (bd). Although its contribution to the overall genetic susceptibility to behcet's disease was estimated to be only 19 percent, the function of the hla-b51 gene has been verified in recent years. In the middle east, the mediterranean region and asia, the prevalence of bd is greatest. The usual starting age is around 30. The ratio of male to females varies according to ethnic context. Bd's cause remains unclear. It is believed to be multifactorial, which includes infectious causes, genetic predisposition, and immune system dysregulation.
Behcet's disease HLA-B51 gene Prevalence predisposition