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Abstract
The aim of the present study is to evaluate the antiepileptic activity of ethanolic extract of tuberous barks of Morinda reticulata gamble in mice. The antiepileptic activity of ethanolic extract of M. reticulata at the doses of 200 and 400 mg/kg, p.o. was evaluated by maximum electroshock (MES), pentylenetetrazole (PTZ) and isoniazid (INH)-induced convulsions in mice. Statistical analysis was carried out by one-way analysis of variance followed by Dunnett's test. In MES method, the chloroform extract significantly protected the mice from convulsions induced by electroshock method in a dose-dependent manner and exhibited more activity at the dose of 400 mg/kg when compared with Phenytoin (25mg/kg p.o) treated animals. In PTZ method, the extract inhibited convulsions in mice potent than standard drug. In INH method, it delayed the latency of convulsions in mice in a dose-dependent manner. The ethanolic extract exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavonoids.