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Sidaacutais a shrub indigenous to pantropical areas, widely distributed in regions and found in pastures, waste lands, cultivated lands, roadsides, lawns and planted forests. Sidaacuta is ethanomedically used as treatment of diuretic, asthma, fever, headache, cough, cold, ulcer, anthelmintic, snake bite, urinary disease, female disorders, sedative, eczema, kidney stone, elephantiasis, testicular swelling, poultice for dandruff, rheumatic affections, facial paralysis, pulmonary tuberculosis and gonorrheae. The phytochemical screening revealed the presence of tannin, saponin, flavonoid, terpenoids, cardio glycoside, vitamin composition and minerals composition was calcium, magnesium, zinc, steroids, phenolic compounds, sesquiterpene, alkaloid cryptolepine, quindoline, quindolinone and fixed oil. The hydro-alcoholic extract of Sidaacuta was for its antihistaminic studies byusing guinea pig ileum and tracheae. The percentage inhibition of hydro-alcoholic extract of Sidaacuta (100µg/ml) onhistamine induced contraction showed 60.6% in comparision with chlorpheniramine (1µg/ml) 69.69%. The present research study draws the conclusion that hydro-alcoholic extract of Sidaacutashowed moderate antihistaminic effect which may be due the combined naturephytoconstituents.