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Heart failure is one of the leading death causes in world which records nearly 20% of deaths in India. Medical therapy, surgical procedures including heart transplantation and cardiac assist devices has only limited efficiency in such condition stem cell therapy represents as the new strategy for better therapeutic outcome. Generally stem cells are derived from few and they generated various organs and tissues. Few scientist has performed research on the stem cell therapy for congestive heart failure condition some of them has shown a good effect. Scientist has to keep effects regarding the development of the cell regeneration therapy with the use of stem cells. Currently in global clinical trails only few trails has been enrolled. At present BMMNC has shown a good effect in heart related treatment.