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Abstract
Objective of the present study to explore the antihyperlipidemic effect of Tecoma stans(T.stans) against monosodium glutamate (MSG) induced obesity in neonatal rats. The studies were carried out on newborn neonatal rats and were injected intraperitoneally with 2 mg/g of MSG on the 2 nd and 4 th postnatal days and 4 mg/g on 6 th , 8 th and 10 th postnatal days. Ethanolic extract (EE) and acetone extract (AE) of T.stans was administered in a dose of 100 and 200 mg/kg, p.o./day at the age of 65 days. On day 60 of treatment, body weight, locomotor activity, body temperature, and various biochemical parameters like serum glucose, total cholesterol, triglyceride, and organs weights were recorded. There was a significant reduction in body weight, organs and increased body temperature, locomotor activity after treatment with extracts. T.stans decreased serum glucose, total cholesterol and triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels and increased high density lipoprotein (HDL) significantly has compared to MSG-control rats.T.stans extracts exhibited antihyperlipidemic effect and it possesses anti-obesity properties in MSG induced obese rats.