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The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and also due to hypersecretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Azadirachta indica. Study was carried out, by using three methods i.e., alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQAI and ALAI, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine. The antiulcer activity of aqueous and alcoholic extracts of Azadirachta indica leaves (AQAI and ALAI) at 250 doses using different experimentally induced gastric ulcer models in rats. Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis.  In alcohol-induced ulcers, AQAI and ALAI were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Azadirachta indica were dose dependent. The results suggest that AQAI and ALAI possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQAI and ALAI can be attributed to its cytoprotective and antisecretory action.


Azadirachta indica antisecretory cytoprotective gastric ulcer alcohol induced ulcers paracetamol-induced ulcers stress induced ulcers

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