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Abstract
To evaluate the antidiabetic and antioxidant activity of Mallotus philippensis extracts of fruits in streptozotocin induced type 2 diabetes in rats and its complication in respect of cardiovascular complications.
Methods
The fruits of Mallotus philippensis were dried under shade and then powdered, and extracted with 1-1.5 liters of methanol by continuous hot percolation using Soxhlet apparatus at boiling point of methanol (62-65.5°C). Preliminary phytochemical studies were also carried out on extract. Diabetes was induced in overnight fasted male albino Wistar rats by a single i.p. injection of STZ at dose of 55 mg/kg. Group I served as untreated normal control while group II was considered as diabetic control. Group III, IV and V diabetic animals were treated with MEMP 150 mg/kg, MEMP 300 mg/kg and glibenclamide 500 mcg/kg b.w. respectively. During the study, body weight and fasting serum glucose level were taken at 0,7th and 15th day.At the end of study, animals in all groups were sacrificed, blood sample, pancreas and liver were collected. Biochemical parameter such as total cholesterol, HDL cholesterol, TG, LDL cholesterol, SGPT, SGOT, SALP, creatinine, and enzymatic antioxidants like SOD, GPx, catalase and lipid peroxidation from liver homogenate were determined. OGTT and histopathological studies of pancreas were performed.
Results
Oral administration of MEMP (150 mg/kg and 300 mg/kg b.w.) showed dose- related antidiabetic and antioxidant activities in diabetic animals, recovery of body weight, and demonstrated a significant reduction in fasting serum glucose, hypolipidaemic effect, protective effect on pancreas, reduction in serum transaminase and creatinine level.