Main Article Content
Abstract
Objective
The Ficus racemosa fruits of used for folklore medicine to the treatment of Antianxiety and Antidepressant activity of ethanolic fruits extract of Ficus racemosa Linn on mice model.
Methods
Evaluation of anxiolytic study (Elevated plus maze, open field test, light and dark model). Evaluation of Depressant study (Tail suspension, forced swim test).
Results EPM
The ethanolic fruits extract of Ficus racemosais 200mg/kg, significantly (P<0.001) increase the time spent in open arm and increase the same dose 400mg/kg, (P<0.001) increased the time spent in neutral zone. L&D - decrease the time spent in dark zone and increase time spent in light zone. The both extract of 200mg/kg and 400mg/kg, significantly (P<0.001) OFT- increased the total locomotion. increased total time spent in central compartment while 400mg/kg significantly(P<0.05) increase the total time spent in central compartment. FST - The significantly 400mg/kg significantly reduce the immobility, the dose near to standard drugs. TSM - The significantly 200mg/kg (P<0.05) increase the struggling time to 15%, and the animal treated with 400mg/kg significantly (<0.01) increased the struggling time by increases30%.the result shows the antidepressant activity by tail suspension activity.
Conclusion
Ethanolic fruits extract contain b-sitisterol (steroidal compounds) flavonoids, it may possible the mechanism of anxiolytic and sedative action. we can conclude that ethanolic extract of Ficus racemosa possess the Antianxiety and Antidepressant activity for both dose level which comparable with the standard drugs (Benzodiazepine).